The WNT signal transduction cascade is a main regulator of development throughout the
animal kingdom. Wnts are also key drivers of most types of tissue stem cells in adult …

The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

Mammalian Wnt proteins are believed to act as short-range signals,,,, yet have not been
previously visualized in vivo. Self-renewal, proliferation and differentiation are coordinated …

There were multiple prerequisites to the evolution of multicellular animal life, including the
generation of multiple cell fates (" cellular diversity") and their patterned spatial arrangement …

How animals establish and pattern the primary body axis is one of the most fundamental
problems in biology. Data from diverse deuterostomes (frog, fish, mouse, and amphioxus) …

Developmental signals such as Wnts are often presented to cells in an oriented manner. To
examine the consequences of local Wnt signaling, we immobilized Wnt proteins on beads …

The asymmetric cell division of stem cells, which produces one stem cell and one
differentiating cell, has emerged as a mechanism to balance stem cell self-renewal and …

Stomata are innovations of land plants that allow regulated gas exchange. Stomatal
precursor cells are produced by asymmetric cell division, and once formed, signal their …

Abstract Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved
mechanism that polarizes cells along specific axes in a tissue. Genetic screens in …

Although many vertebrate organs, such as kidneys, lungs and liver, are composed of
epithelial tubules, little is known of the mechanisms that establish the length or diameter of …