Branched chain amino acids (BCAAs), leucine, isoleucine and valine, are essential amino
acids widely studied for their crucial role in the regulation of protein synthesis mainly through …

Oxidative and nitrosative stress are widely recognized as critical factors in the pathogenesis
and progression of Alzheimer disease (AD) and its earlier stage, amnestic mild cognitive …

Neuroinflammation caused by the disorder of gut microbiota and its metabolites is
associated with the pathogenesis of Parkinson's disease (PD). Thus, it is necessary to …

The metabolic heterogeneity and metabolic interplay between cells are known as significant
contributors to disease treatment resistance. However, with the lack of a mature high …

Deficiency of dietary choline, an essential nutrient, is observed worldwide, with~ 90% of
Americans being deficient. Previous work highlights a relationship between decreased …

Background Plasma metabolomic profile is disturbed in dementia patients, but previous
studies have discordant conclusions. Methods Circulating metabolomic data of 110,655 …

Alzheimer's disease (AD) is a central nervous system disease characterised by
degenerative cognitive dysfunction and memory loss. In a society where the global …

This comprehensive narrative review explores the concept of neuro-vulnerability in energy
metabolism regulation and its implications for metabolic disorders. The review highlights the …

Alzheimer's disease (AD) is the most common neurodegenerative disorders presenting with
the pathological hallmarks of amyloid plaques and tau tangles. Over the past few years …

Leucine restriction (LR) improves insulin resistance and promotes white adipose tissue
browning. However, the effect of LR on obesity-associated cognitive impairment remains …