Asthma is chronic inflammation of the airways characterized by airway hyper-
responsiveness, wheezing, cough, and dyspnea. Asthma affects> 350 million people …

The unique architecture of the mammalian lung is required for adaptation to air breathing at
birth and thereafter. Understanding the cellular and molecular mechanisms controlling its …

Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types.
The role of endothelial cells (EC) in lung fibrosis is poorly understood. Using single cell RNA …

The clinical manifestations of asthma are caused by obstruction of the conducting airways of
the lung. Two airway cell types are critical for asthma pathogenesis: epithelial cells and …

Compartmentalization of the gastrointestinal (GI) tract of metazoans is critical for health. GI
compartments contain specific microbiota, and microbiota dysbiosis is associated with …

Many organs throughout the body maintain epithelial homeostasis by employing a mucosal
barrier which acts as a lubricant and helps to preserve a near-sterile epithelium. Goblet cells …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor
and is also intimately involved in tumorigenesis. FOXM1 stimulates cell proliferation and cell …

Rationale: Inactivating mutations in the Forkhead Box transcription factor F1 (FOXF1) gene
locus are frequently found in patients with alveolar capillary dysplasia with misalignment of …

Idiopathic pulmonary fibrosis (IPF) is a chronic disease with high mortality and is refractory to
treatment. Pulmonary macrophages can both promote and repress fibrosis, however …