In recent decades, mass spectrometry has moved more than ever before into the front line of
protein-centered research. After being established at the qualitative level, the more …

Clinical analysis of blood is the most widespread diagnostic procedure in medicine, and
blood biomarkers are used to categorize patients and to support treatment decisions …

The extracellular matrix (ECM) is a complex assembly of proteins that constitutes the scaffold
organizing cells, tissues, and organs. Over the past decade, mass-spectrometry-based …

Consistent and accurate quantification of proteins by mass spectrometry (MS)-based
proteomics depends on the performance of instruments, acquisition methods and data …

Targeted proteomics technique has emerged as a powerful protein quantification tool in
systems biology, biomedical research, and increasing for clinical applications. The most …

The myriad of peptides presented at the cell surface by class I and class II major
histocompatibility complex (MHC) molecules are referred to as the immunopeptidome and …

Currently data-dependent acquisition (DDA) is the method of choice for mass spectrometry-
based proteomics discovery experiments, but data-independent acquisition (DIA) is steadily …

Introduction Advances in high-resolution mass spectrometry have created renewed interest
for studying global lipid biochemistry in disease and biological systems. Objectives Here, we …

Introduction: While selected/multiple-reaction monitoring (SRM or MRM) is considered the
gold standard for quantitative protein measurement, emerging data-independent acquisition …

This paper reviews methods for detecting proteins based on molecular digitization, ie, the
isolation and detection of single protein molecules or singulated ensembles of protein …