Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

The aggregation of alpha synuclein (α‐syn) is a neuropathological feature that defines a
spectrum of disorders collectively termed synucleinopathies, and of these, Parkinson's …

Previous studies demonstrate that intrastriatal injections of fibrillar alpha-synuclein (α-syn)
into mice induce Parkinson's disease (PD)-like Lewy body (LB) pathology formed by …

Persistent microglia-mediated neuroinflammation is a major pathophysiological contributor
to the progression of Parkinson's disease (PD), but the cell-signaling mechanisms governing …

Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting
approximately onepercent of the population over the age of sixty. Although many animal …

GLT-1 (EAAT2; slc1a2) is the major glutamate transporter in the brain, and is predominantly
expressed in astrocytes, but at lower levels also in excitatory terminals. We generated a …

Background Converging evidence suggests a role for microglia-mediated
neuroinflammation in Parkinson's disease (PD). Animal models of PD can serve as a …

Abstract Alpha-Synuclein (α-syn) is by far the most highly vetted pathogenic and therapeutic
target in Parkinson's disease. Aggregated α-syn is present in sporadic Parkinson's disease …

α-Synuclein physiologically chaperones SNARE-complex assembly at the synapse but
pathologically misfolds into neurotoxic aggregates that are characteristic for …

Rodents emit ultrasonic vocalizations (USVs) to communicate the presence of positive or
negative emotional states and to coordinate social interactions. On this basis, USVs are …