Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …

Covering: 1900 to 2011 The study of biologically active natural products has resulted in
seminal contributions to our understanding of living systems. In the case of electrophilic …

Plants, marine organisms, and microorganisms have evolved complex chemical defense
and signaling systems that are designed to protect them from predators and provide other …

The accuracy of five docking programs at reproducing crystallographic structures of
complexes of 8 macrolides and 12 related macrocyclic structures, all with their …

Nanomedicine greatly improves the efficiency in the delivery of antitumor drugs into the
tumor, but insufficient tumoral penetration impairs the therapeutic efficacy of most …

The microtubule (MT) associated protein tau, which is highly expressed in the axons of
neurons, is an endogenous MT-stabilizing agent that plays an important role in axonal …

Multidrug resistance (MDR) is a major obstacle to the effective treatment of cancer. Cellular
overproduction of P‐glycoprotein (P‐gp), which acts as an efflux pump for various anticancer …

Activity‐based protein profiling (ABPP) has matured into a standard method for the fast,
sensitive, and selective identification of enzyme activity and inhibitors in proteomes. By …

Covering: late 2008 to August 2013 Nature has yielded numerous classes of chemically
distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel …

Microtubules are essential to cell transport, signaling, and mitosis. An increasing range of
anticancer drugs interferes with the normal formation and function of microtubules. Vinca …