Insulin resistance and pancreatic β-cell dysfunction are major pathological mechanisms
implicated in the development and progression of type 2 diabetes (T2D). Beyond the …

Type 2 diabetes mellitus (T2DM) the most prevalent metabolic disease that has evolved into
a major public health issue. Concerning about its secondary complications, a growing body …

The pancreatic islets are composed of discrete hormone-producing cells that orchestrate
systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell …

Oxidative stress is a major component of cell damage and cell fat, and as such, it occupies a
central position in the pathogenesis of metabolic disease. Nuclear factor-erythroid-derived 2 …

Oxidative stress is the leading player in the onset and development of various diseases. The
Keap1-Nrf2 pathway is a pivotal antioxidant system that preserves the cells' redox balance. It …

The progressive and generalized loss of skeletal muscle mass and function, also known as
sarcopenia, underlies disability, increasing adverse outcomes and poor quality of life in …

Prospective epidemiological studies concur in an association between habitual coffee
consumption and a lower risk of type 2 diabetes. Several aspects of these studies support a …

Preventing islet β‐cells death is crucial for treating type 2 diabetes mellitus (T2DM).
Currently, clinical drugs are being developed to improve the quality of T2DM care and self …

Diabetes mellitus is etiologically classified into type 1, type 2 and other types of diabetes.
Despite distinct etiologies and pathogenesis of these subtypes, many studies have …

The beta-cell identity gene, pancreatic duodenal homeobox 1 (Pdx1), plays critical roles in
many aspects of the life of beta-cells including differentiation, maturation, function, survival …