Airway geometry, airway flow, and particle measurement methods: implications on pulmonary drug delivery
Introduction: The effectiveness of drug delivery to the lungs is inextricably linked to the
fundamental interactions that occur between particles and flow in the extrathoracic airway …
fundamental interactions that occur between particles and flow in the extrathoracic airway …
Understanding pressurized metered dose inhaler performance
Introduction: Deepening the current understanding of the factors governing the performance
of the pressurized metered dose inhaler (pMDI) has the potential to benefit patients by …
of the pressurized metered dose inhaler (pMDI) has the potential to benefit patients by …
Characterization of hydrogen jets considering leakage from high-pressure storage tanks using shadowgraphy
The unsteady characteristics of pinhole-ejected ultrahigh-pressure hydrogen jets in the near
field are investigated by the PIV and FFT-IFFT analysis of time-series shadowgraph images …
field are investigated by the PIV and FFT-IFFT analysis of time-series shadowgraph images …
Volatile propellant droplet evaporation measurements in metered dose inhaler sprays
DJ Duke, HN Scott, AJ Kusangaya… - Aerosol Science and …, 2023 - Taylor & Francis
Many aerosol products rely on the rapid vaporization of volatile propellants to produce a fine
spray. In the simplest case, these are binary mixtures of propellant and a delivered product …
spray. In the simplest case, these are binary mixtures of propellant and a delivered product …
A CFD investigation on the aerosol drug delivery in the mouth–throat airway using a pressurized metered-dose inhaler device
Inhalation therapy involving a pressurized metered-dose inhaler (pMDI) is one of the most
commonly used and effective treatment methods for patients with asthma. The purpose of …
commonly used and effective treatment methods for patients with asthma. The purpose of …
Increasing the fine particle fraction of pressurised metered dose inhaler solutions with novel actuator shapes
In this paper we demonstrate that the use of multiple orifices can improve the fine particle
fraction (FPF) of pressurised metered-dose inhaler solution formulations by up to 75% when …
fraction (FPF) of pressurised metered-dose inhaler solution formulations by up to 75% when …
Drug distribution transients in solution and suspension-based pressurised metered dose inhaler sprays
DJ Duke, HN Scott, AJ Kusangaya… - International Journal of …, 2019 - Elsevier
This paper presents in situ time-resolved drug mass fraction measurements in pressurised
metered dose inhaler (PMDI) sprays, using a novel combination of synchrotron X-ray …
metered dose inhaler (PMDI) sprays, using a novel combination of synchrotron X-ray …
[HTML][HTML] Effects of nozzle size and surface hydrophobicity on microbubble generation
Microbubble dynamics in distilled water were experimentally investigated during three
stages: formation, expansion, and detachment, emphasizing the combined effects of nozzle …
stages: formation, expansion, and detachment, emphasizing the combined effects of nozzle …
Temporally and spatially resolved x-ray fluorescence measurements of in-situ drug concentration in metered-dose inhaler sprays
Purpose Drug concentration measurements in MDI sprays are typically performed using
particle filtration or laser scattering. These techniques are ineffective in proximity to the …
particle filtration or laser scattering. These techniques are ineffective in proximity to the …
Investigating the linear dynamics of the near-field of a turbulent high-speed jet using dual-Particle Image Velocimetry (PIV) and Dynamic Mode Decomposition (DMD)
The quest for the physical mechanisms underlying turbulent high-speed jet flows is
underpinned by the extraction of spatio-temporal coherent structures from their flow fields …
underpinned by the extraction of spatio-temporal coherent structures from their flow fields …