Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting up to 30% of the
general adult population. NAFLD encompasses a histological spectrum ranging from pure …

Lysosomal acid lipase (LAL) is the sole enzyme known to degrade neutral lipids in the
lysosome. Mutations in the LAL-encoding LIPA gene lead to rare lysosomal lipid storage …

Acute pancreatitis (AP) is a common gastrointestinal disease and the leading cause of
hospital admission and healthcare burden among gastrointestinal disorders in many …

Lysosomal acid lipase (LAL) plays a key role in intracellular lipid metabolism. Reduced LAL
activity promotes increased multi-organ lysosomal cholesterol ester storage, as observed in …

Lysosomal acid lipase (LAL), encoded by the gene LIPA, is the sole neutral lipid hydrolase
in lysosomes, responsible for cleavage of cholesteryl esters and triglycerides into their …

Aims It has been hypothesized that the activity of lysosomal acid lipase (LAL), a key enzyme
involved in lipid metabolism, is involved in the NAFLD phenotype. To clarify the role of LAL …

OBJECTIVES: To investigate whether blood total lysosomal acid lipase activity (BT-LAL)
levels are uniquely associated with the noncirrhotic and cirrhotic stages of nonalcoholic fatty …

Abstract Background and Aims Recent evidence showed a reduced activity of the lysosomal
acid lipase (LAL) in patients with non‐alcoholic fatty liver disease (NAFLD) and cryptogenic …

Lysosomal storage diseases (LSDs) are a heterogeneous group of inherited disorders
caused by loss-of-function mutations in genes encoding for lysosomal enzymes/proteins …

Recent studies demonstrated reduced blood lysosomal acid lipase (LAL) activity in patients
with nonalcoholic fatty liver disease (NAFLD). We aimed to verify hepatic LAL protein …