The amyloid-β pathway in Alzheimer's disease
Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …
Recent advances in microfluidic technology for bioanalysis and diagnostics
Microfluidics has become a mature technology, providing an excellent toolbox for the
handling and manipulation of fluid samples, suspended cells, and particles. About 30 years …
handling and manipulation of fluid samples, suspended cells, and particles. About 30 years …
Label-free microfluidic cell sorting and detection for rapid blood analysis
N Lu, HM Tay, C Petchakup, L He, L Gong, KK Maw… - Lab on a Chip, 2023 - pubs.rsc.org
Blood tests are considered as standard clinical procedures to screen for markers of diseases
and health conditions. However, the complex cellular background (> 99.9% RBCs) and …
and health conditions. However, the complex cellular background (> 99.9% RBCs) and …
A degradative to secretory autophagy switch mediates mitochondria clearance in the absence of the mATG8-conjugation machinery
HWS Tan, G Lu, H Dong, YL Cho, A Natalia… - Nature …, 2022 - nature.com
PINK1-Parkin mediated mitophagy, a selective form of autophagy, represents one of the
most important mechanisms in mitochondrial quality control (MQC) via the clearance of …
most important mechanisms in mitochondrial quality control (MQC) via the clearance of …
Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine
Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …
small-molecule probes. These molecular tools have been widely applied for interrogating …
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
Y Yin, H Chen, Y Wang, L Zhang… - Journal of extracellular …, 2021 - Wiley Online Library
Cellular senescence is a persistently hypoproliferative state with diverse stressors in a
specific aging microenvironment. Senescent cells have a double‐edged sword effect: they …
specific aging microenvironment. Senescent cells have a double‐edged sword effect: they …
Extracellular vesicles in blood: sources, effects, and applications
A Alberro, L Iparraguirre, A Fernandes… - International Journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) are important players for intercellular communication. EVs are
secreted by almost all cell types; they can transfer information between nearby or distant …
secreted by almost all cell types; they can transfer information between nearby or distant …
Emerging methods in biomarker identification for extracellular vesicle‐based liquid biopsy
Extracellular vesicles (EVs) are released by many cell types and distributed within various
biofluids. EVs have a lipid membrane‐confined structure that allows for carrying unique …
biofluids. EVs have a lipid membrane‐confined structure that allows for carrying unique …
Clinically accurate diagnosis of Alzheimer's disease via multiplexed sensing of core biomarkers in human plasma
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, affecting one in
ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is …
ten people aged over 65 years. Despite the severity of the disease, early diagnosis of AD is …
The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD biomarkers
NJ Ashton, A Leuzy, TK Karikari… - European journal of …, 2021 - Springer
Purpose The development of blood biomarkers that reflect Alzheimer's disease (AD)
pathophysiology (phosphorylated tau and amyloid-β) has offered potential as scalable tests …
pathophysiology (phosphorylated tau and amyloid-β) has offered potential as scalable tests …