Mitochondrial function declines during ageing owing to the accumulation of deleterious
mitochondrial genomes and damage resulting from the localized generation of reactive …

Aging is characterized by the accumulation of damage and other deleterious changes,
leading to the loss of functionality and fitness. Age-related changes occur at most levels of …

Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …

Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins
encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a …

Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces
cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We …

Aging and age-related neurodegeneration are both associated with the accumulation of
unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis …

During development and cellular differentiation, tissue-and cell-specific programs mediate
mitochondrial biogenesis to meet physiological needs. However, environmental and …

Dietary restriction (DR) increases lifespan and attenuates age‐related phenotypes in many
organisms; however, the effect of DR on longevity of individuals in genetically …

There are many mechanisms of lifespan extension, including the disruption of insulin/insulin-
like growth factor 1 (IGF-1) signaling, metabolism, translation, and feeding. Despite the …

Time-or age-dependent accumulation of mitochondrial damage and dysfunction is strongly
associated with aging [1]. Thus, a major biomedical goal is to identify and therapeutically …