During development of the mammalian nervous system, neural stem cells generate neurons
first and glia second, thereby allowing the initial establishment of neural circuitry, and …

The bone morphogenetic proteins (BMPs) are a group of powerful morphogens that are
critical for development of the nervous system. The effects of BMP signaling on neural stem …

The inference of transcriptional networks that regulate transitions into physiological or
pathological cellular states remains a central challenge in systems biology. A mesenchymal …

Glial fibrillary acidic protein (GFAP) is the major intermediate filament protein in astrocytes,
one of the most abundant cell types in the vertebrate central nervous system (CNS) …

In recent years, a link between the transcriptional regulators of lineage-specific gene
expression and progenitor proliferation control has emerged. A main exponent of this …

Curcumin is a natural phenolic component of yellow curry spice, which is used in some
cultures for the treatment of diseases associated with oxidative stress and inflammation …

Deregulation of signaling pathways, through mutation or other molecular changes, can
ultimately result in disease. The tyrosine phosphatase Shp2 has emerged as a major …

Precursor cells of the embryonic cortex sequentially generate neurons and then glial cells,
but the mechanisms regulating this neurogenic-to-gliogenic transition are unclear. Using …

Cultured embryonic cortical progenitor cells will mimic the temporal differentiation pattern
observed in vivo, producing neurons first and then glia. Here, we investigated the role of two …

Manic-depressive illness has been conceptualized as a neurochemical illness. However,
brain imaging and postmortem studies reveal gray-matter reductions, as well as neuronal …