Microbiome risk profiles as biomarkers for inflammatory and metabolic disorders

A Metwaly, S Reitmeier, D Haller - Nature reviews Gastroenterology & …, 2022 - nature.com
The intestine harbours a complex array of microorganisms collectively known as the gut
microbiota. The past two decades have witnessed increasing interest in studying the gut …

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

A Lavelle, H Sokol - Nature reviews Gastroenterology & hepatology, 2020 - nature.com
A key role of the gut microbiota in the establishment and maintenance of health, as well as in
the pathogenesis of disease, has been identified over the past two decades. One of the …

Gut microbiome structure and metabolic activity in inflammatory bowel disease

EA Franzosa, A Sirota-Madi, J Avila-Pacheco… - Nature …, 2019 - nature.com
The inflammatory bowel diseases (IBDs), which include Crohn's disease (CD) and ulcerative
colitis (UC), are multifactorial chronic conditions of the gastrointestinal tract. While IBD has …

[HTML][HTML] Microbiota-derived indole metabolites promote human and murine intestinal homeostasis through regulation of interleukin-10 receptor

EE Alexeev, JM Lanis, DJ Kao, EL Campbell… - The American journal of …, 2018 - Elsevier
Interactions between the gut microbiota and the host are important for health, where
dysbiosis has emerged as a likely component of mucosal disease. The specific constituents …

Alterations of the skin and gut microbiome in psoriasis and psoriatic arthritis

I Olejniczak-Staruch, M Ciążyńska… - International journal of …, 2021 - mdpi.com
Numerous scientific studies in recent years have shown significant skin and gut dysbiosis
among patients with psoriasis. A significant decrease in microbiome alpha-diversity …

Reduced abundance of butyrate-producing bacteria species in the fecal microbial community in Crohn's disease

K Takahashi, A Nishida, T Fujimoto, M Fujii, M Shioya… - Digestion, 2016 - karger.com
Background: The global alteration of the gut microbial community (dysbiosis) plays an
important role in the pathogenesis of inflammatory bowel diseases (IBDs). However …

Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease

JU Scher, C Ubeda, A Artacho, M Attur… - Arthritis & …, 2015 - Wiley Online Library
Objective To characterize the diversity and taxonomic relative abundance of the gut
microbiota in patients with never‐treated, recent‐onset psoriatic arthritis (PsA). Methods …

Gut–skin axis: unravelling the connection between the gut microbiome and psoriasis

AYK Thye, YR Bah, JWF Law, LTH Tan, YW He… - Biomedicines, 2022 - mdpi.com
Evidence has shown that gut microbiome plays a role in modulating the development of
diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The …

Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions

LS Zhang, SS Davies - Genome medicine, 2016 - Springer
Mass spectrometry-and nuclear magnetic resonance-based metabolomic studies comparing
diseased versus healthy individuals have shown that microbial metabolites are often the …

Immune regulation by microbiome metabolites

CH Kim - Immunology, 2018 - Wiley Online Library
Commensal microbes and the host immune system have been co‐evolved for mutual
regulation. Microbes regulate the host immune system, in part, by producing metabolites. A …