[HTML][HTML] Unveiling the potential of Muscadine grape Skin extract as an innovative therapeutic intervention in cancer treatment

S Otun, I Achilonu, V Odero-Marah - Journal of functional foods, 2024 - Elsevier
The use of muscadine grape extracts (MGSE). in cancer treatment has gained attention due
to its distinctive composition of polyphenols and antioxidants. This review analyses the …

Biophysical description of Bromosulfophthalein interaction with the 28-kDa glutathione transferase from Schistosoma japonicum

K Pooe, M Thulo, H Makumbe, B Akumadu… - Molecular and …, 2022 - Elsevier
Glutathione transferases (GSTs) are major detoxification enzymes vital for the survival and
reproduction of schistosomes during infection in humans. Schistosoma encode two GST …

Maillard browning inhibition by ellagic acid via its adduct formation with the Amadori rearrangement product

H Cui, Z Wang, M Ma, K Hayat, Q Zhang… - Journal of agricultural …, 2021 - ACS Publications
The Maillard reaction performed under a stepwise increase of temperature was applied for
researching the inhibition of Maillard browning caused by ellagic acid. Ellagic acid was …

[HTML][HTML] Ligand based-design of potential schistosomiasis inhibitors through QSAR, homology modeling, molecular dynamics, pharmacokinetics, and DFT studies

C Saudatu, A Uzairu, A Chandra, MS Sallau… - Journal of Taibah …, 2024 - Elsevier
Schistosomiasis, also known as bilharzia or snail fever, is a tropical disease caused by
parasitic flatworms belonging to the Schistosoma genus. This disease remains a prevalent …

High-throughput virtual screening and empirical validation of probable inhibitors of Plasmodium falciparum and vivax glutathione transferase using …

O Onisuru, I Achilonu - International Journal of Biological Macromolecules, 2025 - Elsevier
Abstract Plasmodium falciparum Glutathione S-Transferase (PfGST) and Plasmodium vivax
Glutathione S-Transferase (PvGST) play vital roles in detoxification and parasite survival …

Engineering a Pseudo-26-kDa Schistosoma Glutathione Transferase from bovis/haematobium for Structure, Kinetics, and Ligandin Studies

N Padi, BO Akumadu, O Faerch, C Aloke, V Meyer… - Biomolecules, 2021 - mdpi.com
Glutathione transferases (GSTs) are the main detoxification enzymes in schistosomes.
These parasitic enzymes tend to be upregulated during drug treatment, with Schistosoma …

[HTML][HTML] In-silico exploration and structure-based design of Praziquantel derivatives as potential inhibitors of schistosoma mansoni Glutathione S-transferase (SmGST)

SC Jáafaru, A Uzairu, MS Sallau, GI Ndukwe… - Scientific African, 2024 - Elsevier
Schistosomiasis is a chronic parasitic disease with significant public health challenges due
to the limited number of treatment options and increasing levels of drug resistance against …

Describing the ligandin properties of Plasmodium falciparum and vivax glutathione transferase towards bromosulfophthalein from empirical and computational …

O Onisuru, I Achilonu - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
Research has spotlighted glutathione transferase (GST) as a promising target for
antimalarial drug development due to its pivotal role in cellular processes, including …

Comparative structural analysis of the human and Schistosoma glutathione transferase dimer interface using selective binding of bromosulfophthalein

A Valli, I Achilonu - Proteins: Structure, Function, and …, 2022 - Wiley Online Library
The binding channel of Schistosoma glutathione transferase (S GST) has been identified to
possess a non‐substrate site implicated in enzyme inhibition. This binding channel is …

Molecular dynamics-derived pharmacophores of Schistosoma glutathione transferase in complex with bromosulfophthalein: Screening and analysis of potential …

A Valli, I Achilonu - Journal of Molecular Graphics and Modelling, 2023 - Elsevier
Schistosoma glutathione transferases (GSTs) have been identified as attractive drug targets
for the design of novel antischistosomals. Here, we used in silico methods to validate the …