Membranes under the magnetic lens: a dive into the diverse world of membrane protein structures using Cryo-EM
Membrane proteins are highly diverse in both structure and function and can, therefore,
present different challenges for structure determination. They are biologically important for …
present different challenges for structure determination. They are biologically important for …
Molecular basis for redox control by the human cystine/glutamate antiporter system xc−
Cysteine plays an essential role in cellular redox homoeostasis as a key constituent of the
tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability …
tripeptide glutathione (GSH). A rate limiting step in cellular GSH synthesis is the availability …
Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1
JL Parker, T Kato, G Kuteyi, O Sitsel… - Nature Structural & …, 2023 - nature.com
In mammals, the kidney plays an essential role in maintaining blood homeostasis through
the selective uptake, retention or elimination of toxins, drugs and metabolites. Organic anion …
the selective uptake, retention or elimination of toxins, drugs and metabolites. Organic anion …
[HTML][HTML] The PfRCR complex bridges malaria parasite and erythrocyte during invasion
The symptoms of malaria occur during the blood stage of infection, when parasites invade
and replicate within human erythrocytes. The PfPCRCR complex, containing PfRH5 (refs.,) …
and replicate within human erythrocytes. The PfPCRCR complex, containing PfRH5 (refs.,) …
Mechanism of lipid droplet formation by the yeast Sei1/Ldb16 Seipin complex
Lipid droplets (LDs) are universal lipid storage organelles with a core of neutral lipids, such
as triacylglycerols, surrounded by a phospholipid monolayer. This unique architecture is …
as triacylglycerols, surrounded by a phospholipid monolayer. This unique architecture is …
Structural basis of directional switching by the bacterial flagellum
The bacterial flagellum is a macromolecular protein complex that harvests energy from uni-
directional ion flow across the inner membrane to power bacterial swimming via rotation of …
directional ion flow across the inner membrane to power bacterial swimming via rotation of …
Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals
The SLC15 family of proton-coupled solute carriers PepT1 and PepT2 play a central role in
human physiology as the principal route for acquiring and retaining dietary nitrogen. A …
human physiology as the principal route for acquiring and retaining dietary nitrogen. A …
Structural basis of antifolate recognition and transport by PCFT
Folates (also known as vitamin B9) have a critical role in cellular metabolism as the starting
point in the synthesis of nucleic acids, amino acids and the universal methylating agent S …
point in the synthesis of nucleic acids, amino acids and the universal methylating agent S …
Developing graphene grids for cryoelectron microscopy
H Fan, F Sun - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Cryogenic electron microscopy (cryo-EM) single particle analysis has become one of the
major techniques used to study high-resolution 3D structures of biological macromolecules …
major techniques used to study high-resolution 3D structures of biological macromolecules …
Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6
L Dietz, CJ Ellison, C Riechmann, CK Cassidy… - Science, 2023 - science.org
Certain inhibitor of apoptosis (IAP) family members are sentinel proteins that prevent
untimely cell death by inhibiting caspases. Antagonists, including second mitochondria …
untimely cell death by inhibiting caspases. Antagonists, including second mitochondria …