Glutamatergic agents for the treatment of cocaine use disorder
H Hadizadeh, JM Flores, T Mayerson… - Current Behavioral …, 2022 - Springer
Abstract Purpose of Review Disruptions in glutamate hemostasis have been implicated in
cocaine use disorder (CUD). This manuscript reviews novel agents that influence glutamate …
cocaine use disorder (CUD). This manuscript reviews novel agents that influence glutamate …
Abuse liability of mitragynine assessed with a self-administration procedure in rats
K Yue, TA Kopajtic, JL Katz - Psychopharmacology, 2018 - Springer
Rationale Substantial use of the plant kratom for psychoactive effects has driven interest in
its abuse liability. Several place conditioning studies suggest abuse liability of the active …
its abuse liability. Several place conditioning studies suggest abuse liability of the active …
FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder
Post-traumatic stress disorder (PTSD) leads to enhanced alcohol drinking and development
of alcohol use disorder (AUD). Identifying shared neural mechanisms might help discover …
of alcohol use disorder (AUD). Identifying shared neural mechanisms might help discover …
Pharmacological Treatments for Methamphetamine Use Disorder: Current Status and Future Targets
JR Yates - Substance Abuse and Rehabilitation, 2024 - Taylor & Francis
The illicit use of the psychostimulant methamphetamine (METH) is a major concern, with
overdose deaths increasing substantially since the mid-2010s. One challenge to treating …
overdose deaths increasing substantially since the mid-2010s. One challenge to treating …
Relative reinforcing effects of dibutylone, ethylone, and N-ethylpentylone: Self-administration and behavioral economics analysis in rats
M Lai, D Fu, Z Xu, H Du, H Liu, Y Wang, P Xu… - …, 2022 - Springer
Rationale Following the emergence of methylone as one of the most popular synthetic
cathinones, this group of novel psychoactive substance with names ending in “-lone,” such …
cathinones, this group of novel psychoactive substance with names ending in “-lone,” such …
A comparison of reinforcing effectiveness and drug-seeking reinstatement of 2-fluorodeschloroketamine and ketamine in self-administered rats
H Du, M Lai, D Zhuang, D Fu, Y Zhou… - Frontiers in Molecular …, 2022 - frontiersin.org
2-Fluorodeschloroketamine (2F-DCK), a structural analog of ketamine, has been reported to
cause impaired consciousness, agitation, and hallucination in abuse cases. It has similar …
cause impaired consciousness, agitation, and hallucination in abuse cases. It has similar …
Differences in drug intake levels (high versus low takers) do not necessarily imply distinct drug user types: insights from a new cluster-based model
DM Castaneda, M Job - bioRxiv, 2024 - biorxiv.org
Background: Classifying psychostimulant users as high and low responders based on
median split of drug intake levels has face-validity: these appear to be different types of drug …
median split of drug intake levels has face-validity: these appear to be different types of drug …
N‐Isopropylbenzylamine‐induced conditioned place preference, sensitization behaviour and self‐administration in rodents
M Lai, D Fu, X Li, D Zhuang, M Wang, Z Xu… - Addiction …, 2024 - Wiley Online Library
Abstract N‐Isopropylbenzylamine (N‐ipb), a chain isomer of methamphetamine (METH) with
similar physical properties, has been used as a substitute for METH in seized drug samples …
similar physical properties, has been used as a substitute for METH in seized drug samples …
Potent and selective NOP receptor activation reduces cocaine self‐administration in rats by lowering hedonic set point
Developing new medications for the treatment of cocaine dependence continues to be a
research priority. Compelling evidence indicates that mixed opioid receptor agonists …
research priority. Compelling evidence indicates that mixed opioid receptor agonists …
Pharmacological classification of centrally acting drugs using EEG in freely moving rats: an old tool to identify new atypical dopamine uptake inhibitors
Atypical dopamine uptake inhibitors (DUIs) bind to the dopamine transporter and inhibit the
reuptake of dopamine but have lower abuse potential than psychostimulants. Several …
reuptake of dopamine but have lower abuse potential than psychostimulants. Several …