Accurate indel calling plays an important role in precision medicine. A benchmarking indel
set is essential for thoroughly evaluating the indel calling performance of bioinformatics …

Differentiation between phenotypically neutral and disease-causing genetic variation
remains an open and relevant problem. Among different types of variation, non-frameshifting …

Background Variant interpretation is essential for identifying patients' disease-causing
genetic variants amongst the millions detected in their genomes. Hundreds of Variant Impact …

The discrimination of driver from passenger mutations has been a hot topic in the field of
cancer biology. Although recent advances have improved the identification of driver …

An emerging type of therapeutic agent, anticancer peptides (ACPs), has attracted attention
because of its lower risk of toxic side effects. However process of identifying ACPs using …

Insertions and deletions (Indels) represent one of the major variation types in the human
genome and have been implicated in diseases including cancer. To study the features of …

Genetic variation data is nowadays easy to generate. Variation interpretation means the
description of the significance of variations, often in relation to disease. This is substantially …

Abstract Background The Cancer Genome Atlas identified four molecular subgroups of
endometrial cancer with survival differences based on whole genome, transcriptomic, and …

Inframe insertion/deletion (indel) variants may alter protein sequence and function, which
are closely related to an extensive variety of diseases. Although recent researches have …

Identification of driver genes from mass non-functional passenger genes in cancers is still a
critical challenge. Here, an effective and no parameter algorithm, named DriverSubNet, is …