Background Characterizing the mutations selected by the integrase strand transfer inhibitor
(INSTI) dolutegravir and their effects on susceptibility is essential for identifying viruses less …

Antiretroviral therapy has been imperative in controlling the human immunodeficiency virus
(HIV) epidemic. Most low-and middle-income countries have used nucleoside reverse …

Objectives We evaluated whether implementation of lockdown orders in South Africa
affected ambulatory clinic visitation in rural Kwa-Zulu Natal (KZN). Design Observational …

Background Many countries are now replacing non-nucleoside reverse transcriptase
inhibitor (NNRTI)-based first-line antiretroviral therapy (ART) with a regimen containing …

Background There are few data assessing the uptake of first-line dolutegravir among men
and women living with HIV in low-income and middle-income countries, and subsequent …

Introduction There are positive aspects regarding the prescribing of fixed dose combinations
(FDCs) versus prescribing the medicines separately. However, these have to be balanced …

The global public health community has set ambitious treatment targets to end the HIV/AIDS
pandemic. With the notable absence of a cure, the goal of HIV treatment is to achieve …

Substantial progress has been made this century in bringing millions of people living with
HIV into care, but progress for early HIV diagnosis has stalled. Individuals first diagnosed …

Abstract Background South Africa has the largest public antiretroviral therapy (ART)
programme in the world. We assessed temporal trends in pretreatment HIV-1 drug …

Introduction: Concerns about dolutegravir (DTG) tolerability in the real-life setting have
recently arisen. We aimed to estimate the risk of treatment discontinuation and virological …