A comprehensive review on pyrimidine analogs-versatile scaffold with medicinal and biological potential

J Basha, NM Goudgaon - Journal of Molecular Structure, 2021 - Elsevier
Pyrimidines are nitrogen-containing heterocycles known for anticancer, anti-HIV, antifungal,
and antibacterial activities. Pyrimidines, compounds bearing this heterocycle, are common …

Recent advancements in the development of heterocyclic anti-inflammatory agents

S Sharma, D Kumar, G Singh, V Monga… - European Journal of …, 2020 - Elsevier
Most of the anti-inflammatory drugs in clinical practice are becoming outdated owing to their
potential side and adverse effects. These are found to be highly unsafe for long term use …

Design, synthesis of new 1, 2, 4-triazole/1, 3, 4-thiadiazole with spiroindoline, imidazo [4, 5-b] quinoxaline and thieno [2, 3-d] pyrimidine from isatin derivatives as …

AA Abu-Hashem, SA Al-Hussain - Molecules, 2022 - mdpi.com
The current work aims to design and synthesis a new series of isatin derivatives and greatly
enhances their cytotoxic activity. The derivatives 3-((bromophenyl) imino)-1-(morpholino …

Recent biological applications of heterocyclic hybrids containing s-triazine scaffold

MI Ali, MM Naseer - RSC advances, 2023 - pubs.rsc.org
s-Triazine possesses an auspicious status in the field of drug discovery and development
owing to its presence in many naturally occurring compounds as well as commercially …

Synthesis and antimicrobial activity of new 1, 2, 4‐triazole, 1, 3, 4‐oxadiazole, 1, 3, 4‐thiadiazole, thiopyrane, thiazolidinone, and azepine derivatives

AA Abu‐Hashem - Journal of Heterocyclic Chemistry, 2021 - Wiley Online Library
oxo‐4‐phenylbutanehydrazide 3 was reacted with aryl or alkyl isothiocyanates to give the
corresponding N‐substituted‐2‐(4‐oxo‐4‐phenylbutanoyl) hydrazine‐1‐carbothioamide 4a …

Regioselective synthesis and computational calculation studies of some new pyrazolyl‐pyridine and bipyridine derivatives

AM Farag, NA Kheder, AM Fahim… - Journal of Heterocyclic …, 2023 - Wiley Online Library
Abstract Starting from 3‐oxo‐N‐(3‐pyridyl) butanamide, as key intermediate, the title
compounds were synthesized in good yields. Reaction of the pyridine‐carboxamide 1 with …

[HTML][HTML] Thiazole ring-the antimicrobial, anti-inflammatory, and anticancer active scaffold

S Hosseininezhad, A Ramazani - Arabian Journal of Chemistry, 2023 - Elsevier
Background Thiazole ring is one of the most important heterocycle scaffolds in organic and
medicinal chemistry due to this scaffold being the backbone of numerous drugs and their …

The Synthesis, Antimicrobial Activity, and Molecular Docking of New 1, 2, 4-Triazole, 1, 2, 4-Triazepine, Quinoline, and Pyrimidine Scaffolds Condensed to Naturally …

AA Abu-Hashem, SA Al-Hussain - Pharmaceuticals, 2022 - mdpi.com
This study aims to synthesize a new series of furochromone derivatives, evaluate their
antimicrobial properties, and improve the permeability of potent compounds to inhibit …

Synthetic and reactions routes to tetrahydrothieno [3, 2-b] quinoline derivatives (Part IV)

AA Abu-Hashem, AAM Abdelgawad… - Mini-Reviews in …, 2022 - ingentaconnect.com
This review describes the synthesis and chemical reactivity of tetrahydrothieno [3, 2-b]
quinoline derivatives through many reagents such as; 1, 2-dihydropyridine-3-carbonitrile; 1 …

Synthesis, design, and antimicrobial activity of pyrido[2,3‐d][1,2,4]triazolo[4,3‐a]pyrimidinones based on quinoline derivatives

AA Abu‐Hashem, MNM Yousif… - Journal of the …, 2023 - Wiley Online Library
Abstract The pyrido [2, 3‐d] pyrimidine moieties are one of the most biologically widespread
heterocyclic compounds as antimicrobial, antioxidant, antitubercular, antiviral and anti …