Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …

Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

The NMDA-R hypofunction model of schizophrenia started with the clinical observation of
the precipitation of psychotic symptoms in patients with schizophrenia exposed to PCP or …

Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …

Glutamate (Glu) and gamma-aminobutyric acid (GABA) are implicated in the
pathophysiology of major depressive disorder (MDD). GABA levels or GABAergic …

Cognitive impairment has been observed in patients with various psychiatric disorders,
including schizophrenia, major depressive disorder (MDD), and bipolar disorder (BD) …

Background Diminished synaptic gain—the sensitivity of postsynaptic responses to neural
inputs—may be a fundamental synaptic pathology in schizophrenia. Evidence for this is …

In this review article we have consolidated the imaging literature of patients with
schizophrenia across the full spectrum of modalities in radiology including computed …

Glutamatergic dysfunction is implicated in schizophrenia pathoaetiology, but this may vary in
extent between patients. It is unclear whether inter-individual variability in glutamate is …