Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people
hospitalized with severe COVID-19 illness has engendered considerable interest in the …

Although SARS-CoV-2 infects the upper respiratory tract, we know little about the amount,
type, and kinetics of antibodies (Ab) generated in the oral cavity in response to COVID-19 …

Severe cases of COVID‐19 are associated with extensive lung damage and the presence of
infected multinucleated syncytial pneumocytes. The viral and cellular mechanisms …

The Coronaviridae are a family of viruses that cause disease in humans ranging from mild
respiratory infection to potentially lethal acute respiratory distress syndrome. Finding host …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cell entry starts with
membrane attachment and ends with spike (S) protein–catalyzed membrane fusion …

Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane
fusion events caused by the same machinery that underlies viral entry. These syncytia are …

Interferon‐induced transmembrane proteins (IFITMs) restrict infections by many viruses, but
a subset of IFITMs enhance infections by specific coronaviruses through currently unknown …

An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of
immunity. Knowledge about this interplay can not only help us identify biological …

Syncytia are formed when individual cells fuse. SARS-CoV-2 induces syncytia when the
viral spike (S) protein on the surface of an infected cell interacts with receptors on …