Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …

At least nine closely related isoforms of adenylyl cyclases (ACs), the enzymes responsible
for the synthesis of cyclic AMP (cAMP) from ATP, have been cloned and characterized in …

Cloning of multiple opioid receptors has presented opportunities to investigate the
mechanisms of multiple opioid receptor signaling and the regulation of these signals. The …

Stimulus-secretion coupling is an essential process in secretory cells in which regulated
exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While …

The second messenger cAMP has been extensively studied for half a century, but the
plethora of regulatory mechanisms controlling cAMP synthesis in mammalian cells is just …

The present review focuses on the potential physiological regulations involving different
isoforms of adenylyl cyclase (AC), the enzymatic activity responsible for the synthesis of …

Oedema factor, a calmodulin-activated adenylyl cyclase, is important in the pathogenesis of
anthrax. Here we report the X-ray structures of oedema factor with and without bound …

Adenylyl cyclases are a critically important family of multiply regulated signalling molecules.
Their susceptibility to many modes of regulation allows them to integrate the activities of a …

Cyclic AMP (cAMP) plays a key regulatory role in most types of cells; however, the pathways
controlled by cAMP may present important differences between organisms and between …

The discovery of 3!, 5!-cyclic adenosine monophosphate (cAMP) in the late 1950s by
Sutherland and co-workers was the pivotal event that led to our current paradigm of …