Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Significance: A growing body of clinical and experimental evidence has challenged the
traditional understanding that only the adaptive immune system can mount immunological …

Intake of processed foods has increased markedly over the past decades, coinciding with
increased microvascular diseases such as chronic kidney disease (CKD) and diabetes …

In breast cancer, the increased stiffness of the extracellular matrix is a key driver of
malignancy. Yet little is known about the epigenomic changes that underlie the tumorigenic …

Several mechanisms of action have been proposed for DNA methyltransferase and histone
deacetylase inhibitors (DNMTi and HDACi), primarily based on candidate-gene approaches …

Gene set enrichment tests (aka functional enrichment analysis) are among the most
frequently used methods in computational biology. Despite this popularity, there are …

The molecular signatures of epigenetic regulation and chromatin architectures are
fundamental to genetically determined biological processes. Covalent and post-translational …

Cerebral ischemia leads to neuroinflammation and activation of microglia which further
contribute to stroke pathology. Understanding regulation of microglial activation will aid in …

To systematically define molecular features in human tumor cells that determine their degree
of sensitivity to human allogeneic natural killer (NK) cells, we quantified the NK cell …

Ketone bodies have emerged as central mediators of metabolic health, and multiple
beneficial effects of a ketogenic diet, impacting metabolism, neuronal pathologies and, to a …