As a progressive, irreversible neurodegenerative disease, Alzheimer's disease (AD)
continues to be a serious public health problem worldwide. Currently, the most available …

Cyclodextrins (CDs) are cyclic oligosaccharides able to improve drug water solubility and
stability by forming CD/drug inclusion complexes. To further increase drug entrapment and …

In the present work, complexes of simvastatin (SIM) with polysaccharide arabinogalactan
(AG) or disodium salt of glycyrrhizin acid (Na 2 GA) have been prepared using …

Celastrol (Cela), a pentacyclic triterpenoid, has been explored widely due to its broad
therapeutic activity such as antioxidant, chemotherapeutic, neuroprotective etc. However …

The solubility-permeability interplay deals with the question: what is the concomitant effect
on the drug's apparent permeability when increasing the apparent solubility with a solubility …

Several therapeutically active molecules are poorly water-soluble, thereby creating a
challenge for pharmaceutical scientists to develop an active solution for their oral drug …

The recent approval of edaravone has provided an intravenous option to treat amyotrophic
lateral sclerosis (ALS) in addition to the existing oral agent, riluzole. The present work was …

This study applies the 'Flexible-Acceptor'variant of the General Solubility Equation, GSE (Φ,
B), to the prediction of the aqueous intrinsic solubility, log10 S 0, of FDA recently-approved …

Cyclodextrin complex of nintedanib was prepared aiming for increased bio-activity and
improved transport across intestinal membrane with reduced p-glycoprotein (p-gp) efflux …

The objective of this study was to improve the dissolution and solubility of dexibuprofen
(DEX) using hydroxypropyl beta cyclodextrin (HPβCD) inclusion complexes and also to …