The stem cell/material interface is a complex, dynamic microenvironment in which the cell
and the material cooperatively dictate one another's fate: the cell by remodelling its …

The ability of cells to sense and respond to mechanical signals is vital in development and
healthy tissue functioning. Many diseases are related to either changing mechanical …

Stem cells regulate their fate by binding to, and contracting against, the extracellular matrix.
Recently, it has been proposed that in addition to matrix stiffness and ligand type, the degree …

Neural stem cells are multipotent cells with the ability to differentiate into neurons,
astrocytes, and oligodendrocytes. Lineage specification is strongly sensitive to the …

Cells actively sense and process mechanical information that is provided by the extracellular
environment to make decisions about growth, motility and differentiation. It is important to …

It is increasingly clear that mechanotransduction pathways play important roles in regulating
fundamental cellular functions. Of the basic mechanical functions, the determination of …

Stem cells interpret signals from their microenvironment while simultaneously modifying the
niche through secreting factors and exerting mechanical forces. Many soluble stem cell cues …

Osteogenic glue that reproduces the natural bone composition represents the final frontier of
orthopedic adhesives with the potential to revolutionize surgical strategies against …

Extracellular matrix (ECM) stiffness induces focal adhesion assembly to drive malignant
transformation and tumor metastasis. Nevertheless, how force alters focal adhesions to …

Advances in biomaterial science have allowed for unprecedented insight into the ability of
material cues to influence stem cell function. These material approaches better recapitulate …