β-Carboline as a privileged scaffold for multitarget strategies in Alzheimer's disease therapy

A Beato, A Gori, B Boucherle… - Journal of Medicinal …, 2021 - ACS Publications
The natural β-carboline alkaloids display similarities with neurotransmitters that can be
favorably exploited to design bioactive and bioavailable drugs for Alzheimer's disease (AD) …

Natural products inhibitors of the enzyme acetylcholinesterase

JM Barbosa Filho, KCP Medeiros… - Revista Brasileira de …, 2006 - SciELO Brasil
Alzheimer's disease (AD) is a progressive, neurodegenerative pathology that primarily
affects the elderly population, and is estimated to account for 50-60% of dementia cases in …

Current progress in the chemistry and pharmacology of akuammiline alkaloids

A Ramirez, S García-Rubio - Current medicinal chemistry, 2003 - ingentaconnect.com
Akuammiline alkaloids are a family of monoterpene indole alkaloids of renewed medicinal
interest. These bases act as ligands for a heterogeneous group of molecular targets and …

Recent progress in the chemistry of the monoterpenoid indole alkaloids

JE Saxton - Natural Product Reports, 1997 - pubs.rsc.org
Volume 48 in the Manske–Cordell series of monographs includes a very useful survey, by
Sévenet and Pusset, of the alkaloids from the medicinal plants of New Caledonia, which …

Natural product inhibitors of acetylcholinesterase

K Hostettmann, A Borloz, A Urbain… - Current Organic …, 2006 - ingentaconnect.com
Various natural products, such as physostigmine, have long been recognized as inhibitors of
the enzyme acetylcholinesterase. Since the recent approval of galanthamine for the …

Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme

MT Andrade, JA Lima, AC Pinto, CM Rezende… - Bioorganic & medicinal …, 2005 - Elsevier
Ten indole alkaloids from the chloroform extract of stalk of Tabernaemontana australis
(Müell. Arg) Miers were tentatively identified by GC–MS, viz., coronaridine (1), voacangine …

Alkaloids of the aspidospermine group

JE Saxton - The Alkaloids: Chemistry and Biology, 1998 - Elsevier
The alkaloids of the aspidospermine group have not been surveyed in this series since
Cordell's review in Volume 17 (1), which covered the area up to 1977. The present chapter …

Isolation and biological activity of azocine and azocane alkaloids

S Lee, J Sperry - Bioorganic & Medicinal Chemistry, 2022 - Elsevier
Thousands of known alkaloids contain a nitrogen (N) heterocycle. While five-, six-and seven-
membered N-heterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and …

Enantioselective construction of quaternary stereocenters via organocatalytic arylation of isoxazolin-5-ones with o-quinone diimides

R Torán, E Portillo, A Sanz-Marco, C Vila… - Organic Chemistry …, 2023 - pubs.rsc.org
A bifunctional squaramide derived from Cinchona alkaloid catalyzes the enantioselective
arylation of isoxazolin-5-ones with o-quinone diimides (o-QDIs) to give isoxazolin-5-ones …

[HTML][HTML] Monoterpene indole alkaloids from Vinca minor L.(Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease

R Vrabec, J Maříková, M Ločárek, J Korábečný… - Phytochemistry, 2022 - Elsevier
One undescribed indole alkaloid together with twenty-two known compounds have been
isolated from aerial parts of Vinca minor L.(Apocynaceae). The chemical structures of the …