Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …

Neurodegenerative disorders pose a significant health burden and imprint a debilitative
impact on the quality of life. Importantly, aging is intricately intertwined with the progression …

As secondary plant metabolites, polyphenols are abundant in fruits and vegetables. They
are in high demand because of their many health benefits. However, their low bioavailability …

Neurological diseases place a substantial burden on public health and have a serious
impact on the quality of life of patients. Despite the multifaceted pathological process …

Inhibiting the aggregation of amyloid peptides with endogenous peptides has broad interest
due to their intrinsically high biocompatibility and low immunogenicity. Here, we investigated …

Understanding the dynamic changes of plant biomolecules is vital for exploring their
mechanisms in the environment. Molecular dynamics (MD) simulation has been widely used …

Neurodegenerative disorders (NDDs) are multifaceted complex disorders that have put a
great health and economic burden around the globe nowadays. The multi-factorial nature of …

Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs)
are proteins and protein segments that usually do not acquire well-defined folded structures …

The pathogenesis of Parkinson's disease (PD) is closely linked to the massive presence of
Lewy vesicles and Lewy axons in the cytoplasm of neurons, mainly consisting of α-synuclein …

Abstract α-Synuclein (α-Syn) is a presynaptic neuronal protein whose fibrillar aggregates
accumulate in the form of Lewy bodies in dopaminogenic neurons. This leads to …