mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

mRNA vaccines manufacturing: Challenges and bottlenecks

SS Rosa, DMF Prazeres, AM Azevedo, MPC Marques - Vaccine, 2021 - Elsevier
Vaccines are one of the most important tools in public health and play an important role in
infectious diseases control. Owing to its precision, safe profile and flexible manufacturing …

[HTML][HTML] mRNA vaccines—a new era in vaccinology

N Pardi, MJ Hogan, FW Porter… - Nature reviews Drug …, 2018 - nature.com
Abstract mRNA vaccines represent a promising alternative to conventional vaccine
approaches because of their high potency, capacity for rapid development and potential for …

RNA therapeutics: updates and future potential

C Zhang, B Zhang - Science China Life Sciences, 2023 - Springer
Recent advancements in the production, modification, and cellular delivery of RNA
molecules facilitated the expansion of RNA-based therapeutics. The increasing …

Neoantigens: promising targets for cancer therapy

N Xie, G Shen, W Gao, Z Huang, C Huang… - Signal transduction and …, 2023 - nature.com
Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

Clinical and immunological effects of mRNA vaccines in malignant diseases

A Heine, S Juranek, P Brossart - Molecular cancer, 2021 - Springer
In vitro-transcribed messenger RNA-based therapeutics represent a relatively novel and
highly efficient class of drugs. Several recently published studies emphasize the potential …

The nano delivery systems and applications of mRNA

M Li, Y Li, S Li, L Jia, H Wang, M Li, J Deng… - European journal of …, 2022 - Elsevier
The current COVID-19 epidemic has greatly accelerated the application of mRNA
technology to our real world, and during this battle mRNA has proven it's unique advantages …

mRNA therapeutics in cancer immunotherapy

JD Beck, D Reidenbach, N Salomon, U Sahin… - Molecular cancer, 2021 - Springer
Synthetic mRNA provides a template for the synthesis of any given protein, protein fragment
or peptide and lends itself to a broad range of pharmaceutical applications, including …

Nanoplatforms for mRNA therapeutics

C Meng, Z Chen, G Li, T Welte… - Advanced Therapeutics, 2021 - Wiley Online Library
Abstract mRNA‐based therapeutics are a unique class of drugs for treatment of human
diseases. Since in vitro transcribed mRNA molecules have relatively low stability and their …

Messenger RNA vaccines for cancer immunotherapy: progress promotes promise

AL Huff, EM Jaffee, N Zaidi - The Journal of Clinical …, 2022 - Am Soc Clin Investig
The COVID-19 pandemic has elevated mRNA vaccines to global recognition due to their
unprecedented success rate in protecting against a deadly virus. This international success …