Six shades of vascular smooth muscle cells illuminated by KLF4 (Krüppel-Like Factor 4)
C Yap, A Mieremet, CJM de Vries, D Micha… - … , and vascular biology, 2021 - Am Heart Assoc
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …
The pathophysiology of osteoporosis in obesity and type 2 diabetes in aging women and men: The mechanisms and roles of increased bone marrow adiposity
Osteoporosis is defined as a systemic skeletal disease characterized by decreased bone
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …
mass and micro-architectural deterioration leading to increased fracture risk. Osteoporosis …
[HTML][HTML] Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution
AK Sárvári, EL Van Hauwaert, LK Markussen… - Cell metabolism, 2021 - cell.com
Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …
Multi-omics profiling of mouse gastrulation at single-cell resolution
Formation of the three primary germ layers during gastrulation is an essential step in the
establishment of the vertebrate body plan and is associated with major transcriptional …
establishment of the vertebrate body plan and is associated with major transcriptional …
Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment
Bone marrow mesenchymal lineage cells are a heterogeneous cell population involved in
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …
bone homeostasis and diseases such as osteoporosis. While it is long postulated that they …
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication
Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-
associated fatty liver disease; yet, the mechanisms underlying the progression from the …
associated fatty liver disease; yet, the mechanisms underlying the progression from the …
Loss of KDM4B exacerbates bone-fat imbalance and mesenchymal stromal cell exhaustion in skeletal aging
Skeletal aging is a complex process, characterized by a decrease in bone formation, an
increase in marrow fat, and stem cell exhaustion. Loss of H3K9me3, a heterochromatin …
increase in marrow fat, and stem cell exhaustion. Loss of H3K9me3, a heterochromatin …
Smooth muscle cell reprogramming in aortic aneurysms
The etiology of aortic aneurysms is poorly understood, but it is associated with
atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) …
atherosclerosis, hypercholesterolemia, and abnormal transforming growth factor β (TGF-β) …
[HTML][HTML] Regional specialization and fate specification of bone stromal cells in skeletal development
KK Sivaraj, HW Jeong, B Dharmalingam, D Zeuschner… - Cell Reports, 2021 - cell.com
Bone stroma contributes to the regulation of osteogenesis and hematopoiesis but also to
fracture healing and disease processes. Mesenchymal stromal cells from bone (BMSCs) …
fracture healing and disease processes. Mesenchymal stromal cells from bone (BMSCs) …
Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities
Obesity is a major risk factor for cardiometabolic diseases. Nevertheless, a substantial
proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The …
proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The …