Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

Spatiotemporal gene expression programmes are orchestrated by transcriptional
enhancers, which are key regulatory DNA elements that engage in physical contacts with …

Chromosome structure in mammals is thought to regulate transcription by modulating three-
dimensional interactions between enhancers and promoters, notably through CTCF …

Determining how chromosomes are positioned and folded within the nucleus is critical to
understanding the role of chromatin topology in gene regulation. Several methods are …

Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

In eukaryotes, the genome does not exist as a linear molecule but instead is hierarchically
packaged inside the nucleus. This complex genome organization includes multiscale …

Oncogenes are commonly amplified on particles of extrachromosomal DNA (ecDNA) in
cancer,, but our understanding of the structure of ecDNA and its effect on gene regulation is …

INTRODUCTION Cancer is one of the leading causes of death worldwide. Although the 2%
of the human genome that encodes proteins has been extensively studied, much remains to …

Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …

Diagnosis and treatment of disease demand a sound understanding of the underlying
mechanisms, determining any Achilles' heel that can be targeted in effective therapies …