The aryl hydrocarbon receptor (AHR) is not essential to survival, but does act as a key
regulator of many normal physiological events. The role of this receptor in toxicological …

The zebrafish has become a widely accepted model host for studies of infectious disease,
including fungal infections. The species is genetically tractable, and the larvae are …

During development, animals generate distinct cell populations with specific identities,
functions, and morphologies. We mapped transcriptionally distinct populations across …

Perfluoropolyether carboxylic acids (PFECAs, CF 3 (OCF 2) n COO−, n= 2–5) are novel
alternatives to perfluorooctanoic acid (PFOA) and are widely used in industrial production …

Thyroid hormone system disruption (THSD) negatively affects multiple developmental
processes and organs. In fish, inhibition of deiodinases, which are enzymes crucial for (in) …

The tailbud is the posterior leading edge of the growing vertebrate embryo and consists of
motile progenitors of the axial skeleton, musculature and spinal cord. We measure the 3D …

Immunomodulatory drugs (IMiDs) are important for the treatment of multiple myeloma and
myelodysplastic syndrome. Binding of IMiDs to Cereblon (CRBN), the substrate receptor of …

Many aquatic vertebrates have a remarkable ability to regenerate limbs and tails after
amputation. Previous studies indicate that reactive oxygen species (ROS) signalling initiates …

The fish early‐life stage (FELS) test (Organisation for Economic Co‐operation and
Development [OECD] test guideline 210) is the primary test used internationally to estimate …

Canonical Wnt/β‐catenin signaling has been implicated in multiple developmental events
including the regulation of proliferation, cell fate, and differentiation. In the inner ear, Wnt/β …