Acetate revisited: a key biomolecule at the nexus of metabolism, epigenetics, and oncogenesis–part 2: acetate and ACSS2 in health and disease

JR Moffett, N Puthillathu, R Vengilote… - Frontiers in …, 2020 - frontiersin.org
Acetate, the shortest chain fatty acid, has been implicated in providing health benefits
whether it is derived from the diet or is generated from microbial fermentation of fiber in the …

A review on the role of fatty acids in colorectal cancer progression

M Hoxha, B Zappacosta - Frontiers in Pharmacology, 2022 - frontiersin.org
Colorectal cancer (CRC) is the third leading cause of mortality in cancer patients. The role of
fatty acids (FA) and their metabolism in cancer, particularly in CRC raises a growing interest …

Altering the substrate specificity of acetyl-CoA synthetase by rational mutagenesis of the carboxylate binding pocket

N Sofeo, JH Hart, B Butler, DJ Oliver… - ACS Synthetic …, 2019 - ACS Publications
Acetyl-CoA synthetase (ACS) is a member of a large superfamily of enzymes that display
diverse substrate specificities, with a common mechanism of catalyzing the formation of a …

Gut microbiome as a biomarker for predicting early recurrence of HBV‐related hepatocellular carcinoma

C Zheng, F Lu, B Chen, J Yang, H Yu, D Wang… - Cancer …, 2023 - Wiley Online Library
To investigate the potential of the gut microbiome as a biomarker for predicting the early
recurrence of HBV‐related hepatocellular carcinoma (HCC), we enrolled 124 patients …

[HTML][HTML] Inhibition of ACSS2 triggers glycolysis inhibition and nuclear translocation to activate SIRT1/ATG5/ATG2B deacetylation axis, promoting autophagy and …

J Yang, H Wang, B Li, J Liu, X Zhang, Y Wang, J Peng… - Metabolism, 2025 - Elsevier
Background Metabolic reprogramming is a hallmark of cancer, characterized by a high
dependence on glycolysis and an enhanced utilization of acetate as an alternative carbon …

Effect of short chain fatty acids on age-related disorders

MF Fernandes, S de Oliveira, M Portovedo… - Reviews on New Drug …, 2020 - Springer
Recent studies have indicated a prominent role of intestinal microbiota in regulation of
several physiological aspects of the host including development and activation of the …

[PDF][PDF] Metabolic signatures and potential biomarkers for the diagnosis and treatment of colon cancer cachexia

X Qiu, R Lu, Q He, S Chen, C Huang… - Acta Biochim. Biophys …, 2023 - researchgate.net
Cancer cachexia (CAC) is a debilitating condition that often arises from noncachexia cancer
(NCAC), with distinct metabolic characteristics and medical treatments. However, the …

Diverse stakeholders of tumor metabolism: an appraisal of the emerging approach of multifaceted metabolic targeting by 3-bromopyruvate

S Yadav, SK Pandey, Y Goel, MK Temre… - Frontiers in …, 2019 - frontiersin.org
Malignant cells possess a unique metabolic machinery to endure unobstructed cell survival.
It comprises several levels of metabolic networking consisting of 1) upregulated expression …

Acetic acid application timing on strawberry: an alleviator for salinity adverse effect

Z Mirfattahi, S Eshghi, A Gharaghani, M Etemadi… - Acta Physiologiae …, 2022 - Springer
Salinity is an important abiotic stress which limits normal plant growth and productivity,
particularly in arid and semi-arid areas. The foliar spray of acetic acid has recently been …

Characterization of a novel glucocorticoid-resistant human B-cell acute lymphoblastic leukemia cell line, with AMPK, mTOR and fatty acid synthesis pathway inhibition

Y Li, C Zuo, L Gu - Cancer Cell International, 2021 - Springer
Background Acquired glucocorticoid (GC) resistance remains the main obstacle in acute
lymphoblastic leukemia (ALL) therapy. The aim of the present study was to establish a novel …