L-DOPA (levodopa) is a therapeutic agent which is the most effective medication for treating
Parkinson's disease, but it needs dose optimization, and therefore its analytical …

Introduction: The development of pharmacogenetic-based clinical practice guidelines for the
use of anti-Parkinson's disease drugs requires, as a pre-requisite, the identification and …

Background Integrating green chemistry principles into analytical processes is vital for
sustainability and accuracy. Aim This study is dedicated to finding eco-friendly solutions that …

Chiral detection plays a crucial role in drug development by ensuring the purity and efficacy
of drugs. This enables researchers to accurately identify and quantify chiral molecules …

Sparganii rhizoma (SL) has potential therapeutic effects on gastric cancer (GC), but its main
active ingredients and possible anticancer mechanism are still unclear. In this study, we …

Background: In this study, we developed and validated a HPLC–MS/MS method capable of
simultaneously determining levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa …

A simple, accurate, and reproducible HPLC‐UV method has been developed and validated
for the quantification of levodopa (l‐Dopa) in human plasma. The method involves a simple …

There are ten million people in the world who have Parkinson's disease. The most potent
medicine for Parkinson's disease is levodopa (L-DOPA). However, long-term consumption of …

The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …

New, simple, accurate and sensitive UV spectrophotometric and chemometric methods have
been developed and validated for determination of Entacapone (ENT), Levodopa (LD) and …