Epithelial tight junctions define the paracellular permeability of the intestinal barrier.
Molecules can cross the tight junctions via two distinct size-selective and charge-selective …

Autoimmune diseases, including inflammatory bowel disease, multiple sclerosis and
rheumatoid arthritis, have distinct clinical presentations but share underlying patterns of gut …

There is increasing evidence showing that the dynamic changes in the gut microbiota can
alter brain physiology and behavior. Cognition was originally thought to be regulated only by …

Plasma cells (PC) are found in the CNS of multiple sclerosis (MS) patients, yet their source
and role in MS remains unclear. We find that some PC in the CNS of mice with experimental …

Almost half the cells and 1% of the unique genes found in our bodies are human, the rest
are from microbes, predominantly bacteria, archaea, fungi, and viruses. These …

The state of the intestinal environment can have profound effects on the activity of the central
nervous system through the physiological contributions of the microbiota, regulation of …

There is a growing appreciation of the role of the gut microbiota in all aspects of health and
disease, including brain health. Indeed, roles for the bacterial commensals in various …

Background: Butyric acid (BA) is a short-chain fatty acid (SCFA) with anti-inflammatory
properties, which promotes intestinal barrier function. Medium-chain fatty acids (MCFA) …

Changes in gut microbiota composition and a diverse role of B cells have recently been
implicated in multiple sclerosis (MS), a central nervous system (CNS) autoimmune disease …

Background & Aims The gut microbiome has been suggested to play a role in gut barrier
hemostasis, but data are scarce and limited to animal studies. We therefore aimed to assess …