The solubility of proteins plays a key role in determining the physicochemical properties,
processing, sensory attributes, shelf life, and nutritional profile of foods formulated with …

Disrupted protein folding or decreased protein stability can lead to the accumulation of
(partially) un‐or misfolded proteins, which ultimately cause the formation of protein …

Motivation Poor protein solubility hinders the production of many therapeutic and industrially
useful proteins. Experimental efforts to increase solubility are plagued by low success rates …

Background Protein solubility is a precondition for efficient heterologous protein expression
at the basis of most industrial applications and for functional interpretation in basic research …

In most cases, protein aggregation stems from the establishment of non-native
intermolecular contacts. The formation of insoluble protein aggregates is associated with …

Motivation Solubility and expression levels of proteins can be a limiting factor for large-scale
studies and industrial production. By determining the solubility and expression directly from …

Structural bioinformatics suffers from the lack of interfaces connecting biological structures
and machine learning methods, making the application of modern neural network …

There is intense and widespread interest in developing monoclonal antibodies as
therapeutic agents to treat diverse human disorders. During early-stage antibody discovery …

Antibody drugs have become a key part of biotherapeutics. Patients suffering from various
diseases have benefited from antibody therapies. However, its development process is …

Therapeutic protein, represented by antibodies, is of increasing interest in human medicine.
However, clinical translation of therapeutic protein is still largely hindered by different …