Background Distinct systemic treatments exist for metastatic uveal melanoma. Tebentafusp
and combined immune checkpoint blockade (ICB) with ipilimumab plus anti-PD-1 antibodies …

In health technology assessment (HTA), population‐adjusted indirect comparisons (PAICs)
are increasingly considered to adjust for the difference in the target population between …

In evidence synthesis, effect modifiers are typically described as variables that induce
treatment effect heterogeneity at the individual level, through treatment‐covariate …

Disagreement remains on what the target estimand should be for population-adjusted
indirect treatment comparisons. This debate is of central importance for policy-makers and …

We examine four important considerations in the development of covariate adjustment
methodologies for indirect treatment comparisons. First, we consider potential advantages of …

Objective To compare safety and efficacy of centanafadine versus methylphenidate
hydrochloride extended release (ER; Concerta) in adults with ADHD. Methods Without head …

Population‐adjusted indirect comparison (PAIC) is an increasingly used technique for
estimating the comparative effectiveness of different treatments for the health technology …

In health technology assessment, matching‐adjusted indirect comparison (MAIC) is the most
common method for pairwise comparisons that control for imbalances in baseline …

In evidence synthesis, effect measure modifiers are typically described as variables that
induce treatment effect heterogeneity at the individual level, through treatment-covariate …

Background When studying the association between treatment and a clinical outcome, a
parametric multivariable model of the conditional outcome expectation is often used to …