Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …

An appropriate balance between self-renewal and differentiation is crucial for stem cell
function during both early development and tissue homeostasis throughout life. Recent …

Reactive species, which mainly include reactive oxygen species (ROS), are products
generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells …

Quiescence is a fundamental property that maintains hematopoietic stem cell (HSC) potency
throughout life. Quiescent HSCs are thought to rely on glycolysis for their energy, but the …

Aging is an intricate phenomenon characterized by progressive decline in physiological
functions and increase in mortality that is often accompanied by many pathological …

Advances in metabolomics have deepened our understanding of the roles that specific
modes of metabolism play in programming stem cell fates. Here, we review recent …

The balance between oxidative and nonoxidative glucose metabolism is essential for a
number of pathophysiological processes. By deleting enzymes that affect aerobic glycolysis …

Driver mutations in oncogenic pathways, rewiring of cellular metabolism and altered ROS
homoeostasis are intimately connected hallmarks of cancer. Electrons derived from different …

The forkhead box O (FOXO) transcription factors are considered as tumor suppressors that
limit cell proliferation and induce apoptosis. FOXO gene alterations have been described in …

Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with
antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in …