Rationally designed multi-target drugs (also termed multimodal drugs, network therapeutics,
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …

A variety of acute brain insults can induce epileptogenesis, a complex process that results in
acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis …

Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections …

Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of
patients have drug-refractory seizures and are left with suboptimal therapeutic options such …

Over decades, the prevailing standard in drug discovery was the concept of designing highly
selective compounds that act on individual drug targets. However, more recently, multi-target …

N-methyl-D-aspartate receptors (NMDARs) are widely distributed in the central nervous
system (CNS) and play critical roles in neuronal excitability in the CNS. Both clinical and …

Epilepsy is a neurological disease that transpires due to the unusual synchronized neuronal
discharge within the central nervous system, which drives repetitious unprovoked seizures …

Polysialic acid (polySia) emerges as a novel regulator of microglia activity. We recently
identified polysialylated proteins in the Golgi compartment of murine microglia that are …

Here we describe a novel mouse model of temporal lobe epilepsy (TLE) that moves the site
of kainate injection from the rodent dorsal hippocampus (corresponding to the human …

Stroke is one of the most important causes of acquired epilepsy in the adult population.
While factors such as cortical involvement and haemorrhage have been associated with …