Electroresponsive hydrogels possess a conducting material component and respond to
electric stimulation through reversible absorption and expulsion of water. The high level of …

As an in vivo technique, microdialysis sampling reflects the composition of the extracellular
fluid and can be used in virtually any tissue, organ or biological fluid. Microdialysis has …

Background and purpose: Earlier studies had demonstrated that tonic–clonic seizure‐like
events (SLEs) resembling electrographic correlates of limbic seizures in animals and …

In evaluating drugs that enter or are excluded from the brain, novel pharmaceutical
strategies are needed. For this reason, we have developed a humanized Dynamic In vitro …

Purpose: The multidrug transporter P‐glycoprotein (P‐gp) is expressed at high levels in a
variety of tissues such as the endothelial cells of the blood–brain barrier (BBB) capillaries …

Although there is significant evidence correlating overreacting or perhaps misguided
immune cells and the blood–brain barrier (BBB) with the pathogenesis of neuroinflammatory …

Purpose: A biotechnologic breakthrough for the study of drug permeability across the blood–
brain barrier (BBB) would be the use of a reproducible in vitro model that recapitulates the …

Background The study of the cerebrovascular physiology is crucial to understand the
pathogenesis of neurological disease and the pharmacokinetic of drugs. Appropriate …

Using a rat model which allows serial blood sampling and concurrent brain microdialysis
sampling, we have investigated the temporal kinetic inter‐relationship of levetiracetam in …

P-glycoprotein (Pgp) overexpression in the blood brain barrier (BBB) is hypothesized to
lower brain drug concentrations and thus inhibit anticonvulsant effects in drug-resistant …