Immune escape and metastasis mechanisms in melanoma: breaking down the dichotomy
CA Shirley, G Chhabra, D Amiri, H Chang… - Frontiers in …, 2024 - frontiersin.org
Melanoma is one of the most lethal neoplasms of the skin. Despite the revolutionary
introduction of immune checkpoint inhibitors, metastatic spread, and recurrence remain …
introduction of immune checkpoint inhibitors, metastatic spread, and recurrence remain …
[HTML][HTML] Redefining the tumor microenvironment with emerging therapeutic strategies
S Xu, X Li, W Ma - Oncology Research, 2024 - pmc.ncbi.nlm.nih.gov
The environment surrounding a tumor, known as the tumor microenvironment (TME), plays a
role in how cancer progresses and responds to treatment. It poses both challenges and …
role in how cancer progresses and responds to treatment. It poses both challenges and …
Induced collagen type‐I secretion by hepatocytes of the melanoma liver metastasis is associated with a reduction in tumour‐infiltrating lymphocytes
S Mizuno, MA Bustos, Y Hayashi, K Abe… - Clinical and …, 2024 - Wiley Online Library
Background Overall patients with melanoma liver metastasis (MLiM) have a dismal
prognosis and poor responses to the standard of care treatment. Understanding the role of …
prognosis and poor responses to the standard of care treatment. Understanding the role of …
Advancing drug-response prediction using multi-modal and-omics machine learning integration (MOMLIN): a case study on breast cancer clinical data
MM Rashid, K Selvarajoo - Briefings in Bioinformatics, 2024 - academic.oup.com
The inherent heterogeneity of cancer contributes to highly variable responses to any
anticancer treatments. This underscores the need to first identify precise biomarkers through …
anticancer treatments. This underscores the need to first identify precise biomarkers through …
Differential T cell accumulation within intracranial and subcutaneous melanomas is associated with differences in intratumoral myeloid cells
K Stasiak, AD Stevens, AC Bolte, CT Curley… - Cancer Immunology …, 2025 - Springer
Patients with metastatic brain melanomas (MBM) experience shorter-lasting survival than
patients with extracranial metastases, and this is associated with a higher fraction of …
patients with extracranial metastases, and this is associated with a higher fraction of …
Advances in immunotherapy for mucosal melanoma: harnessing immune checkpoint inhibitors for improved treatment outcomes
Z Shan, F Liu - Frontiers in Immunology, 2024 - frontiersin.org
Mucosal melanoma (MM) poses a significant clinical challenge due to its aggressive nature
and limited treatment options. In recent years, immunotherapy has emerged as a promising …
and limited treatment options. In recent years, immunotherapy has emerged as a promising …
Immunogenomics and spatial proteomic mapping highlight distinct neuro-immune architectures in melanoma vs. non-melanoma-derived brain metastasis
A Mendoza-Valderrey, E Dettmann, D Hanes… - BJC Reports, 2024 - nature.com
Abstract Background Brain metastases (BrMs) are a devastating complication of solid
tumours. A better understanding of BrMs biology is needed to address their challenging …
tumours. A better understanding of BrMs biology is needed to address their challenging …
Targeting mitochondrial metabolism as a promising therapeutic strategy in cancer
ML Stoker - 2024 - ora.ox.ac.uk
Since the discovery of the Warburg effect in the 1920s, our understanding of cancer
metabolism has evolved. Increasing evidence shows cancer cells are metabolically plastic …
metabolism has evolved. Increasing evidence shows cancer cells are metabolically plastic …
Targeting mitochondrial metabolism to improve the tumor microenvironment: A bibliometric study and brief review (1994-2024)
H Zheng, G Wang, J Wu, M Liu, H Cheng - 2024 - researchsquare.com
Background The tumor microenvironment (TME) plays a pivotal role in supporting tumor
growth and metastasis via several inhibitory mechanisms, which diminish the effectiveness …
growth and metastasis via several inhibitory mechanisms, which diminish the effectiveness …