Okadaic acid: more than a diarrheic toxin

V Valdiglesias, MV Prego-Faraldo, E Pásaro, J Méndez… - Marine Drugs, 2013 - mdpi.com
Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is
easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be …

Okadaic acid (OA): Toxicity, detection and detoxification

L Fu, X Zhao, L Ji, J Xu - Toxicon, 2019 - Elsevier
Okadaic acid (OA), a potent polyether marine toxin, accumulates in the digestive glands of
marine mollusks and therefore can severely threaten the health of humans after ingestion of …

A multi-omics approach to elucidate okadaic acid-induced changes in human HepaRG hepatocarcinoma cells

LTD Wuerger, H Sprenger, K Krasikova, M Templin… - Archives of …, 2024 - Springer
Okadaic acid (OA), a prevalent marine biotoxin found in shellfish, is known for causing acute
gastrointestinal symptoms. Despite its potential to reach the bloodstream and the liver, the …

Effects of microorganisms, temperature and irradiation on the stability of dissolved okadaic acid and dinophysistoxin-1 in seawater

J Qiu, C Yin, A Li, Y Yang, G Wang, D Li - Marine Environmental Research, 2025 - Elsevier
Diarrhetic shellfish toxins (DSTs) are widespread in marine environments, posing potential
threats to marine ecosystems, shellfish aquaculture, and human health. Despite their …

Differences in metabolism of the marine biotoxin okadaic acid by human and rat cytochrome P450 monooxygenases

F Kolrep, S Hessel, A These, A Ehlers, K Rein… - Archives of …, 2016 - Springer
The ingestion of seafood contaminated with the marine biotoxin okadaic acid (OA) can lead
to diarrhetic shellfish poisoning with symptoms like nausea, vomiting and abdominal …

Metabolism of okadaic acid by NADPH-dependent enzymes present in human or rat liver S9 fractions results in different toxic effects

F Kolrep, K Rein, A Lampen, S Hessel-Pras - Toxicology in vitro, 2017 - Elsevier
The lipophilic marine biotoxin okadaic acid (OA) represents a natural contaminant produced
by algae accumulating in seafood. Acute intoxications result in diarrhetic shellfish poisoning …

Okadaic acid group toxins: toxicity, exposure routes, and global safety management

K Lee, N Kim, JK Kim, YJ Kim, JS Lee… - Journal of Food Hygiene …, 2023 - koreascience.kr
Okadaic acid (OA) group toxins, including OA and its analogs, such as dinophysis toxins
(DTXs), have been reported to cause diarrheal shellfish poisoning (DSP). These toxins are …

Cdc45/Mcm2-7/GINS complex down-regulation mediates S phase arrest in okadaic acid-induced cell damage

M Feng, M Zhou, L Fu, J Cai, L Ji, J Zhao, J Xu - Toxicon, 2018 - Elsevier
Okadaic acid (OA) is one of the most common and widespread marine toxins and causes
acute gastrointestinal symptoms known as diarrheic shellfish poisoning (DSP) in humans …

Cytotoxicity assays: identification of toxins and mechanism of action

V Fessard - Comprehensive Analytical Chemistry, 2017 - Elsevier
Issues raised by phycotoxins are not of recent concern. Numerous intoxications have been
reported mostly since the 1960s in Europe. The implementation of monitoring programs and …

A novel electrical cell-substrate impedance biosensor for rapid detection of marine toxins

L Zou, N Hu, J Zhou, K Su, Q Wang, L Du, C Wu… - Sensor …, 2014 - ingentaconnect.com
Marine toxins were produced by plankton and do a great harm to human through food chain
by accumulating in shellfishes and fishes. It is highly required and favorable to develop …