The menace of severe adverse events and deaths associated with viral gene therapy and its potential solution

A Kachanov, A Kostyusheva, S Brezgin… - Medicinal Research …, 2024 - Wiley Online Library
Over the past decade, in vivo gene replacement therapy has significantly advanced,
resulting in market approval of numerous therapeutics predominantly relying on adeno …

siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles

MF Cau, F Ferraresso, M Seadler, K Badior… - … Therapy Methods & …, 2024 - cell.com
Genetic manipulation of animal models is a fundamental research tool in biology and
medicine but is challenging in large animals. In rodents, models can be readily developed …

Histamine activates an intracellular Ca2+ signal in normal human lung fibroblast WI-38 cells

R Berra-Romani, A Vargaz-Guadarrama… - Frontiers in Cell and …, 2022 - frontiersin.org
Histamine is an inflammatory mediator that can be released from mast cells to induce airway
remodeling and cause persistent airflow limitation in asthma. In addition to stimulating …

Inhalable Therapies for the Heart: Take the “Lung” Way Home?

JS Hulot, C Kupatt - Journal of the American College of Cardiology, 2024 - jacc.org
Molecular therapies have the potential to revolutionize the way we are managing patients
with cardiovascular diseases. Many targets are involved in abnormal ion balances, deficient …

Gene delivery in a rodent lung transplant model

MG Katz, E Eliyahu, K Ishikawa - The Journal of Thoracic and …, 2024 - jtcvs.org
1. Gao Q, Kahan R, Gonzalez T, et al. Gene delivery followed by ex vivo lung perfusion
using an adeno-associated viral vector in a rodent lung transplant model. J Thorac …

Understanding the Role of Calcium Cycling Genes in Maladaptation of the Right Heart in Response to Pulmonary Hypertension

AJ Ravichandran - 2023 - search.proquest.com
Pulmonary hypertension (PH), a complex disease characterized by an elevated pulmonary
artery pressure, causes severe right heart remodeling and failure in patients. In this …