Over the past decade, in vivo gene replacement therapy has significantly advanced,
resulting in market approval of numerous therapeutics predominantly relying on adeno …

Genetic manipulation of animal models is a fundamental research tool in biology and
medicine but is challenging in large animals. In rodents, models can be readily developed …

Histamine is an inflammatory mediator that can be released from mast cells to induce airway
remodeling and cause persistent airflow limitation in asthma. In addition to stimulating …

Molecular therapies have the potential to revolutionize the way we are managing patients
with cardiovascular diseases. Many targets are involved in abnormal ion balances, deficient …

1. Gao Q, Kahan R, Gonzalez T, et al. Gene delivery followed by ex vivo lung perfusion
using an adeno-associated viral vector in a rodent lung transplant model. J Thorac …

Pulmonary hypertension (PH), a complex disease characterized by an elevated pulmonary
artery pressure, causes severe right heart remodeling and failure in patients. In this …