Individuals who are diagnosed with amyotrophic lateral sclerosis (ALS) today face the same
historically intransigent problem that has existed since the initial description of the disease in …

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting
motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5 …

This review is a primer on the three main mechanisms of cell death: apoptosis, autophagy-
associated cell death, and necrosis. The authors discuss the clinical implications of each of …

Objective: To pool data from completed amyotrophic lateral sclerosis (ALS) clinical trials and
create an open-access resource that enables greater understanding of the phenotype and …

The first reports of disorders that in terms of cognitive and behavioral symptoms resemble
frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, amyotrophic lateral sclerosis and prion-based neurodegeneration are …

Lysosomal storage diseases (LSDs) often manifest with severe systemic and central
nervous system (CNS) symptoms. The existing treatment options are limited and have no or …

Objective To examine the safety and tolerability as well as the preliminary efficacy of
arimoclomol, a heat shock protein co-inducer that promotes nascent protein folding, in …

Neurodegenerative diseases (NDDs) such as Alzheimer's disease, Parkinson's disease and
Huntington's disease (HD), amyotrophic lateral sclerosis, and prion diseases are all …

Sporadic inclusion body myositis (sIBM) is the commonest severe myopathy in patients more
than 50 years of age. Previous therapeutic trials have targeted the inflammatory features of …