Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

Colorectal cancer (CRC) is a leading cause of cancer death worldwide. It includes different
subtypes that differ in their clinical and prognostic features. In the past decade, in addition to …

With the goal of modeling human disease of the large intestine, we sought to develop an
effective protocol for deriving colonic organoids (COs) from differentiated human embryonic …

Colorectal cancer (CRC) is the fourth most common cancer amongst men and women.
Between 3 and 6% of all CRCs are attributed to well-defined inherited syndromes, including …

It is estimated that 20% to 30% of colorectal cancers (CRCs) are familial with 5% to 10%
related to a known genetic syndrome. 1, 2 The hereditary CRCs are broadly divided into …

Oncogenic mutations in BRAF are believed to initiate serrated colorectal cancers; however,
the mechanisms of BRAF-driven colon cancer are unclear. We find that oncogenic BRAF …

Background Gene expression-based profiling of colorectal cancer (CRC) can be used to
identify four molecularly homogeneous consensus molecular subtype (CMS) groups with …

Evidence suggests that up to one fifth of colorectal carcinomas develop from serrated
polyps, named for their pattern of colonic crypts, and include the sessile serrated …

The metabolic and signaling pathways regulating aggressive mesenchymal colorectal
cancer (CRC) initiation and progression through the serrated route are largely unknown …

Background Colorectal adenoma (CRA) is a classical premalignant lesion, with high
incidence and mainly coexisting with hyperplastic polyp (HPP). Hence, this study aimed to …