Potential and therapeutic roles of diosmin in human diseases

E Huwait, M Mobashir - Biomedicines, 2022 - mdpi.com
Because of their medicinal characteristics, effectiveness, and importance, plant-derived
flavonoids have been a possible subject of research for many years, particularly in the last …

[HTML][HTML] Pharmacogenomics: a genetic approach to drug development and therapy

R Qahwaji, I Ashankyty, NS Sannan, MS Hazzazi… - Pharmaceuticals, 2024 - mdpi.com
The majority of the well-known pharmacogenomics research used in the medical sciences
contributes to our understanding of medication interactions. It has a significant impact on …

PGAM1 inhibition promotes HCC ferroptosis and synergizes with anti‐PD‐1 immunotherapy

Y Zheng, Y Wang, Z Lu, J Wan, L Jiang… - Advanced …, 2023 - Wiley Online Library
The combination of immunotherapy and molecular targeted therapy exhibits promising
therapeutic efficacy in hepatocellular carcinoma (HCC), but the underlying mechanism is still …

Deciphering molecular landscape of breast cancer progression and insights from functional genomics and therapeutic explorations followed by in vitro validation

B Khan, R Qahwaji, MS Alfaifi, T Athar, A Khan… - Scientific Reports, 2024 - nature.com
Breast cancer is caused by aberrant breast cells that proliferate and develop into tumors.
Tumors have the potential to spread throughout the body and become lethal if ignored …

Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer

HI Khouja, IM Ashankyty, LH Bajrai, PKP Kumar… - Scientific Reports, 2022 - nature.com
Cancer is among the highly complex disease and renal cell carcinoma is the sixth-leading
cause of cancer death. In order to understand complex diseases such as cancer, diabetes …

Pathobiological functions and clinical implications of annexin dysregulation in human cancers

L Prieto-Fernández, ST Menéndez… - Frontiers in cell and …, 2022 - frontiersin.org
Annexins are an extensive superfamily of structurally related calcium-and phospholipid-
binding proteins, largely conserved and widely distributed among species. Twelve human …

A network-guided approach to discover phytochemical-based anticancer therapy: Targeting MARK4 for hepatocellular carcinoma

S Ahmed, M Mobashir, LA Al-Keridis… - Frontiers in …, 2022 - frontiersin.org
MAP/microtubule affinity-regulating kinase 4 (MARK4) is associated with various biological
functions, including neuronal migration, cell polarity, microtubule dynamics, apoptosis, and …

Genomic profiling and network-level understanding uncover the potential genes and the pathways in hepatocellular carcinoma

SA El-Kafrawy, MM El-Daly, LH Bajrai… - Frontiers in …, 2022 - frontiersin.org
Data integration with phenotypes such as gene expression, pathways or function, and
protein-protein interactions data has proven to be a highly promising technique for …

Global gene expression and docking profiling of COVID-19 infection

A Jabeen, N Ahmad, K Raza - Frontiers in genetics, 2022 - frontiersin.org
Coronavirus is an enclosed positive-sense RNA virus with club-like spikes protruding from
its surface that causes acute respiratory infections in humans. Because it is considered a …

High-sensitive and rapid electrochemical detection of miRNA-31 in saliva using Cas12a-based 3D nano-harvester with improved trans-cleavage efficiency

Y Wu, J Pei, Y Li, G Wang, L Li, J Liu, G Tian - Talanta, 2024 - Elsevier
Salivary miRNA-31 is a reliable diagnostic marker for early-stage oral squamous cell
carcinoma (OSCC), but accurate detection of miRNA-31 in saliva samples is a challenge …