Age-related diseases are frequently linked to pathological immune dysfunction, including
excessive inflammation, autoreactivity and immunodeficiency. Recent analyses of human …

Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

PCIF1 can mediate the methylation of N 6, 2′-O-dimethyladenosine (m6Am) in mRNA. Yet,
the detailed interplay between PCIF1 and the potential cofactors and its pathological …

TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene
expression. Dysregulation of their activity is associated with many serious pathogenic states …

Bi-directional transcription of Human Endogenous Retroviruses (hERVs) is a common
feature of autoimmunity, neurodegeneration and cancer. Higher rates of cancer incidence …

The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and
TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly …

Ten-eleven translocation proteins (TET1-3) are dioxygenases that oxidize 5-
methyldeoxycytosine, thus taking part in passive and active demethylation. TETs have …