Diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) arise from
complex interactions of genetic and environmental factors, with genetic variants regulating …

Contemporary mouse genetic reference populations are a powerful platform to discover
complex disease mechanisms. Advanced high-diversity mouse populations include the …

Host genetic variation has a major impact on infectious disease susceptibility. The study of
pathogen resistance genes, largely aided by mouse models, has significantly advanced our …

The etiologic pathways leading to neuropsychiatric diseases remain poorly defined. As
genomic technologies have advanced over the past several decades, considerable …

Most complex diseases involve genetic and environmental risk factors, engage multiple cells
and tissues, and follow a polygenic or omnigenic model depicting numerous genes …

Multiparental populations (MPPs) encompass greater genetic diversity than traditional
experimental crosses of two inbred strains, enabling broader surveys of genetic variation …

Objective Animal studies remain essential for understanding mechanisms of epilepsy and
identifying new therapeutic targets. However, existing animal models of epilepsy do not …

Two key features of recombinant inbred panels are well-characterized genomes and
reproducibility. Here we report on the sequenced genomes of six additional Collaborative …

Highlights•Imprinted effects in the brain range from monoallelic to parentally-biased
expression.•Imprinted expression is highly specific to brain region, cell type, and …

Rationale Few effective treatments exist for cocaine use disorders due to gaps in knowledge
about its complex etiology. Genetically defined animal models provide a useful tool for …