Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an
endopeptidase activity. Although its primary functions were originally thought to be only of a …

Cathepsin L is a key host cysteine protease utilized by coronaviruses for cell entry and is a
promising drug target for novel antivirals against SARS-CoV-2. The marine natural product …

The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently
demands novel direct antiviral treatments. The main protease (Mpro) and papain-like …

Abstract Chagas disease and Human African Trypanosomiasis (HAT) are caused by
Trypanosoma cruzi and T. brucei parasites, respectively. Cruzain (CRZ) and Rhodesain …

The identity and biological activity of most metabolites still remain unknown. A bottleneck in
the exploration of metabolite structures and pharmaceutical activities is the compound …

The prokaryotic filamentous marine cyanobacteria are photosynthetic microbes that are
found in diverse marine habitats, ranging from epiphytic to endolithic communities. Their …

The cysteine proteases, cruzain and Tbr CATL (rhodesain), are therapeutic targets for
Chagas disease and Human African Trypanosomiasis, respectively. Among the known …

USP7 is highly expressed in a variety of tumors and is thought to play a major role in cancer
development. However, there are no drugs available to target USP7, so there is a need to …

Gallinamide A, a metabolite of the marine cyanobacterium Schizothrix sp., selectively
inhibits cathepsin L-like cysteine proteases. We evaluated the potency of gallinamide A and …