A majority of mitochondrial DNA (mtDNA) mutations reported to be implicated in diseases
are heteroplasmic, a status with coexisting mtDNA variants in a single cell. Quantifying the …

Current practices for performing forensic mitochondrial DNA (mtDNA) sequence analysis, as
employed in public and private laboratories across the United States, have changed …

In the last decades, studies about ageing have become more essential as our population
grows older. The incidence of age-related diseases increases, which pose challenges both …

Mitochondrial point heteroplasmy is a common event observed not only in patients with
mitochondrial diseases but also in healthy individuals. We here report a comprehensive …

The development and maintenance of mitochondrial heteroplasmy has important
consequences for both health and heredity. Previous studies using pathogenic mutations …

Determining the levels of human mitochondrial heteroplasmy is of utmost importance in
several fields. In spite of this, there are currently few published works that have focused on …

Resolution of mitochondrial (mt) DNA heteroplasmy is possible when applying a massively
parallel sequencing (MPS) approach. However, interpretation criteria for matching …

Despite the fact that mitochondrial dysfunctions are increasingly recognized as key
components in stress-related mental disorders, very little is known about the association …

Hairs from the same donor have been found to differ in mtDNA sequence within and among
themselves and from other tissues, which impacts interpretation of results obtained in a …

The insight heterodox genetics of mtDNA infer new perspectives at the level of human
mitochondrial control region heteroplasmy, which is substantial in evolutionary as well as …