[HTML][HTML] Digital pathology and artificial intelligence in translational medicine and clinical practice
V Baxi, R Edwards, M Montalto, S Saha - Modern Pathology, 2022 - Elsevier
Traditional pathology approaches have played an integral role in the delivery of diagnosis,
semi-quantitative or qualitative assessment of protein expression, and classification of …
semi-quantitative or qualitative assessment of protein expression, and classification of …
Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment
Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …
Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning
A principal challenge in the analysis of tissue imaging data is cell segmentation—the task of
identifying the precise boundary of every cell in an image. To address this problem we …
identifying the precise boundary of every cell in an image. To address this problem we …
Molecular biology of Hodgkin lymphoma
MA Weniger, R Küppers - Leukemia, 2021 - nature.com
Classical Hodgkin lymphoma (cHL) is unique among lymphoid malignancies in several key
biological features.(i) The Hodgkin and Reed-Sternberg (HRS) tumor cells are rare among …
biological features.(i) The Hodgkin and Reed-Sternberg (HRS) tumor cells are rare among …
[HTML][HTML] Metabolic modulation of immune checkpoints and novel therapeutic strategies in cancer
Y Wang, Y Wang, Y Ren, Q Zhang, P Yi… - Seminars in cancer …, 2022 - Elsevier
Cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4) or programmed death-1 (PD-
1)/programmed death-ligand 1 (PD-L1)–based immune checkpoint inhibitors (ICIs) have led …
1)/programmed death-ligand 1 (PD-L1)–based immune checkpoint inhibitors (ICIs) have led …
Next frontier in tumor immunotherapy: macrophage-mediated immune evasion
Y Qiu, T Chen, R Hu, R Zhu, C Li, Y Ruan, X Xie… - Biomarker research, 2021 - Springer
Abstract Tumor-associated macrophages (TAMs), at the core of immunosuppressive cells
and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences …
and cytokines networks, play a crucial role in tumor immune evasion. Increasing evidences …
Single-cell transcriptome analysis reveals disease-defining T-cell subsets in the tumor microenvironment of classic Hodgkin lymphoma
T Aoki, LC Chong, K Takata, K Milne, M Hav… - Cancer discovery, 2020 - AACR
Hodgkin lymphoma is characterized by an extensively dominant tumor microenvironment
(TME) composed of different types of noncancerous immune cells with rare malignant cells …
(TME) composed of different types of noncancerous immune cells with rare malignant cells …
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments
Understanding the mechanisms of HIV tissue persistence necessitates the ability to visualize
tissue microenvironments where infected cells reside; however, technological barriers limit …
tissue microenvironments where infected cells reside; however, technological barriers limit …
Targeting the tumor microenvironment in B-cell lymphoma: challenges and opportunities
Y Liu, X Zhou, X Wang - Journal of Hematology & Oncology, 2021 - Springer
B-cell lymphoma is a group of hematological malignancies with high clinical and biological
heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction …
heterogeneity. The pathogenesis of B-cell lymphoma involves a complex interaction …
Targeting immune checkpoints in hematological malignancies
Immune checkpoint blockade (ICB) therapies such as anti-programmed death 1 (PD-1) and
anti-CTLA-4 (cytotoxic T lymphocyte-associated protein 4) have dramatically transformed …
anti-CTLA-4 (cytotoxic T lymphocyte-associated protein 4) have dramatically transformed …